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Norepinephrine and Dopamine Reuptake Inhibitors (NDRIs)

Norepinephrine and Dopamine Reuptake Inhibitors (NDRIs) work on increasing the levels of both norepinephrine and dopamin in the brain. They do this by preventing their reabsorption back into the cells. The increased levels of both neurotransmitters are thought to improve mood and, as a result, decrease depression. Buproprion (Wellbutrin) is the only FDA-approved NDRI on the market.  

Common side effects of this class of medication include:

  • Agitation
  • Nausea
  • Anorexia
  • Hheadache
  • Iinsomnia
  • Increased blood pressure
  • Constipation
  • Shakiness
  • Nervousness
  • Anxiety
  • Dry mouth
  • Rash
  • Sweating
  • Tinnitus
  • Weight Loss
  • Muscle Pain
  • Sore throat
  • And frequent urination.

Since the medication can increase blood pressure in some individuals, it’s important to monitor your levels on a regular basis. Persons with a history of heart disease, seizure and eating disorders should alert their doctor prior to getting a prescription for the medication. An NDRI may not be right for you.

There are potentially dangerous drug interactions, so you must alert your doctor to all the over the counter (OTC) and prescription medications you take in addition to any herbal and dietary supplements. Those with cirrhosis of the liver are not encouraged to take NDIS it can actually cause more liver problems. It’s wise to alert your doctor to all of your medical issues, past and present, before beginning treatment with a noepinephrine and dopamine inhibitor.

If you notice a worsening of your symptoms or the introduction (or increase) of suicidal thoughts, you must notify your doctor immediately. This is a very serious potential side effect.